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Complement‐dependent cytotoxicity or flow cytometric lymphocyte crossmatch (LXM) tests may fail to detect clinically significant antibodies (Abs) against non‐human leukocyte antigen (HLA). A flow cytometric endothelial precursor cell crossmatch (EPCXM) test (XM‐ONE®) is available for detection of Abs against donor endothelial precursor cells (EPCs). We showed that lymphocytes co‐purified with EPCs...
Abnormal human leukocyte antigen G (HLA‐G) expression may be involved in pre‐eclampsia. A 14 bp insertion/deletion polymorphism exists in exon 8 of the HLA‐G gene. Fetal +14/+14 bp HLA‐G genotype may predispose to pre‐eclampsia in the mother. Other polymorphisms, besides the 14 bp polymorphism (rs66554220), in the 3′‐untranslated region (3′‐UTR) (exon 8) of the HLA‐G gene might be associated with...
Human leukocyte antigen (HLA)‐DQA1*0510 has been identified in a Spanish patient diagnosed with celiac disease. DQA1*0510 differs from DQA1*0505/09 by a point mutation at exon 2 producing an amino acid replacement at codon 77 (I>V).
This study was designed to evaluate the relationship between the presence of tumor necrosis factor (TNF) polymorphisms, human leukocyte antigen (HLA)‐DRB1*03 linkage and the prognosis of sarcoidosis. In a retrospective case–control study, TNF‐αG‐308A, TNF‐αG‐238A, lymphotoxin‐α (LTA) and HLA‐DRB1*03 were genotyped in 625 sarcoidosis patients. These patients were classified into 298 patients with persistent...
Human leukocyte antigen (HLA)‐B*4907 was detected in a family from Morocco because of inconsistencies found between molecular and serologic typing results. B*4907 differs from B*490101 by two nucleotide changes in codon 163, producing an amino acid replacement, L>E.
Canine diabetes mellitus (DM) shares many similarities with human type 1 diabetes (T1D). It is a complex genetic disorder, which shows marked differences in breed susceptibility, with Samoyed dogs being highly susceptible, whereas the Boxer breed is relatively resistant. A number of immune response genes, which have been associated with human T1D, have also been implicated in determining susceptibility...
In this study, we investigated human leukocyte antigen (HLA)‐G*0105N and the 14 bp deletion/insertion polymorphism in exon 8 of the HLA‐G gene in 600 individuals from two southern Chinese Han populations (Hunan Han and Guangdong Han) and two northern Chinese populations (Inner Mongolia Han and Inner Mongolia Mongol), we also studied the linkage disequilibrium (LD) between HLA‐G and HLA‐A locus in...
The T‐cell immunoglobulin mucin (TIM) gene family encodes receptors on T‐cells that regulate Th1‐ and Th2‐cell‐mediated immunity. Recently published data implied differential expression of human TIM molecules by mononuclear cells in cerebrospinal fluid of patients with multiple sclerosis (MS) and might therefore be involved in different phases of the pathogenesis of MS. The purpose of this study was...
Strong linkage disequilibrium (LD) is a characteristic of the major histocompatibility complex (MHC) region, as well as the genome in general in dogs as a consequence of demographic changes with domestication. Disease association studies of MHC haplotypes may be affected by high LD and the resultant shared genetic backgrounds of haplotypes giving associations with linked but non‐causative mutations,...
Human leukocyte antigen (HLA)‐DP is considered a target for humoral immune response in clinical transplantation. This study analyses the incidence of HLA‐DP antibodies in renal patients. Development and epitope specificity of donor‐specific antibodies (DSA) and non‐DSA (NDSA) were examined. Pre‐ and posttransplant sera of 338 patients were screened for HLA‐DP antibodies using the luminex single antigen...
The human leukocyte antigen (HLA)‐G non‐classical major histocompatibility complex (MHC) class I molecule was originally described in first‐trimester trophoblasts at the fetal–maternal interface in 1990. Eight years later, the First International Conference on this molecule was inaugurated by Prof Jean Dausset, recipient of the Nobel Prize in Medicine. The Fifth International Conference on HLA‐G,...
This study reports extensive genomic data for both human leukocyte antigen (HLA) class I and II loci in Norwegian Sami, a native population living in the northwest of Europe. The Sami have a distinct culture and their own languages, which belong to the Uralic linguistic family. Norwegian Sami (n = 200) were typed at the DNA level for the HLA‐A, ‐C, ‐B, ‐DRB1 and ‐DQB1 loci, and compared with a non‐Sami...
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